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XRK3F2 B

CAS No. 2375193-43-2

XRK3F2 B( —— )

Catalog No. M33173 CAS No. 2375193-43-2

XRK3F2 is an inhibitor of the p62-ZZ domain, blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 217 Get Quote
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Biological Information

  • Product Name
    XRK3F2 B
  • Note
    Research use only, not for human use.
  • Brief Description
    XRK3F2 is an inhibitor of the p62-ZZ domain, blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo.
  • Description
    XRK3F2 is an inhibitor of p62 (Sequestosome-1)-ZZ/domain.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    Autophagy
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2375193-43-2
  • Formula Weight
    435.89
  • Molecular Formula
    C23H24ClF2NO3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 150 mg/mL (344.12 mM; Ultrasonic )H2O : 0.91 mg/mL (2.09 mM; Ultrasonic)
  • SMILES
    Cl.OCCNCc1ccc(OCc2ccc(F)cc2)c(OCc2ccc(F)cc2)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Adamik J, et al. XRK3F2 Inhibition of p62-ZZ Domain Signaling Rescues Myeloma-Induced GFI1-Driven Epigenetic Repression of the Runx2 Gene in Pre-osteoblasts to Overcome Differentiation Suppression. Front Endocrinol (Lausanne). 2018 Jun 29;9:344.?
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